1055 Cutaneous dermatophyte infections as a marker of prediabetic hyperglycemia

Patients with type 1 and 2 diabetes have higher rates for all infections, including cutaneous mycoses. Pathogenic mechanisms increased infections in include a hyperglycemic environment defects innate immunity, among others. Specifically, is known risk factor onychomycosis dermatophyte infections. However, less about the prevalence of tinea individuals an (known as prediabetes, defined Hgb A1c 5.7-6.4%). The study objective was to assess whether skin and/or nails could represent surrogate marker elevated prediabetic patients. Tinea cases were identified by ICD codes compared randomly selected controls who lacked diagnosis tinea. values at 90, 90-180, 180-360 days preceding clinic visit interest identified. Odds given averaged pre-visit A1c’s evaluated using univariable multivariable logistic regression. We 22,092 random least one year, along 8,450 cases. Types included unguium (n=5628, 66.6%), corporis (n=855,10.1%), cruris (n=610, 7.2%), pedis (n=1750, 20.7%), capitis/barbae (n=101, 1.2%), multiple types (n=534, 6.3%). older more likely peripheral vascular disease. Higher score associated odds (OR=1.23, 1.21-1.25), 25% each unit increase A1c. This relationship remained unchanged after adjusting demographics, disease, immune-related disorders, tobacco use (OR=1.12, 1.10-1.15). findings suggest that increasing values, even when within range (5.7-6.4%), are or nails. Therefore, fungal may important predictor development hyperglycemia.